ABSTRACT
Introduction: Screening for vertically transmitted infection is mandatory and must be conducted at the first prenatal consultation. The most vulnerable women's groups are those at the lowest socio-economic level. Dried blood spot testing on filter paper could represent a secure way to screen pregnant women in the prenatal period. Methods: A cross-sectional study was conducted between November 2009 and March 2010, in the Metropolitan Region of Salvador, Bahia, Brazil, to compare the accuracy of the dried blood spot in filter paper and venipuncture serological as screening methods for HIV, HTLV, VHB, VHC, Treponema pallidum, and Toxoplasma gondii during prenatal period. Results of the venous blood sample collected in tubes were considered the gold standard. Results: Serum samples and dried blood spot were obtained from 692 pregnant women aged between 14 and 42 years, with a median age of 26. Thirteen women were seropositive for T. gondii (1.88%; 95% CI: 0.60–2.71%), five for T. pallidum (0.72%; 95% CI: 0.15–1.61%), two for HBV (0.29%; 95% CI: 0.050.95%) and one for HTLV-1 (0.14%; 95% CI: 0.01–0.71%). No one was positive for HCV and HIV. The dried blood spot accuracy for syphilis and HTLV were 100% (95% CI: 99.25–100) and 100% (95% CI: 99.45–100%), respectively. The average time between blood collection and recording of the sample in the reference laboratory was 4.93 (3.82) days and between dried blood spot processing and active search for pregnant women was 3.44 (4.27) days. Conclusions: The use of dried blood spot may represent a secure way to expedite access to results of vertically transmitted diseases in the prenatal period, particularly in regions with scarce healthcare resources. .
Subject(s)
Adolescent , Adult , Female , Humans , Pregnancy , Young Adult , Dried Blood Spot Testing/methods , Pregnancy Complications, Infectious/diagnosis , Brazil/epidemiology , Cross-Sectional Studies , HIV Infections/diagnosis , HIV Infections/epidemiology , HTLV-I Infections/diagnosis , HTLV-I Infections/epidemiology , HTLV-II Infections/diagnosis , HTLV-II Infections/epidemiology , Hepatitis B/diagnosis , Hepatitis B/epidemiology , Hepatitis C/diagnosis , Hepatitis C/epidemiology , Prenatal Diagnosis , Prevalence , Reproducibility of Results , Syphilis/diagnosis , Syphilis/epidemiology , Toxoplasmosis/diagnosis , Toxoplasmosis/epidemiologyABSTRACT
A síndrome de Churg-Strauss é uma doença sistêmica rara caracterizada principalmente por hipereosinofilia, asma e vasculite. O pulmão é o órgão mais frequentemente envolvido. Neste relato, descrevemos uma alteração relativamente rara nesta doença - a presença de um nódulo pulmonar -, ao mesmo tempo que recordamos os principais achados obtidos em exames radiológicos e os seus diagnósticos diferenciais mais importantes.
Churg-Strauss syndrome is a rare systemic disease primarily characterized by hypereosinophilia, asthma and vasculitis. The lung is the organ most frequently involved. In the present report, the authors describe a relatively rare finding in this disease - the presence of a pulmonary nodule -, while recalling the main radiological findings and the most relevant differential diagnoses.